Systematic review and meta-analysis of oxidative stress and antioxidant markers in recurrent aphthous stomatitis

We performed this systematic review and meta-analysis to synthesize all studies that reported the level of oxidative and antioxidative markers in recurrent aphthous stomatitis (RAS) patients compared to controls. We registered our study in PROSPERO (CRD42023431310). PubMed, ProQuest, Scopus, EMBASE,...

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Published in:BMC oral health 2023-12, Vol.23 (1), p.960-960, Article 960
Main Authors: Ghasemi, Saeideh, Farokhpour, Fataneh, Mortezagholi, Bardia, Movahed, Emad, Ghaedi, Arshin, Gargari, Morad Kohandel, Khanzadeh, Monireh, Bazrgar, Aida, Khanzadeh, Shokoufeh
Format: Article
Language:English
Subjects:
Agreements
Antioxidants
Aphthous
Aphthous stomatitis
Biomarkers
Care and treatment
Comparative analysis
Development and progression
Diagnosis
Free radicals
Glutathione peroxidase
Health aspects
Humans
Illnesses
Measurement
Medical research
Medicine, Experimental
Meta-analysis
Oxidants
Oxidative Stress
Software
Stomatitis
Stomatitis, Aphthous
Superoxide
Systematic review
Thiols
Uric Acid
Vitamin E
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Summary:We performed this systematic review and meta-analysis to synthesize all studies that reported the level of oxidative and antioxidative markers in recurrent aphthous stomatitis (RAS) patients compared to controls. We registered our study in PROSPERO (CRD42023431310). PubMed, ProQuest, Scopus, EMBASE, Google Scholar, and Web of Science were searched to find relevant publications up to June 5, 2023. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. We included 30 articles after multiple stags of screening. We found that erythrocyte superoxide dismutase and Glutathione peroxidase activity were significantly lower in patients with RAS compared to healthy controls (SMD = - 1.00, 95%CI = -1.79 to -0.21, p = 0.013, and SMD = - 1.90, 95%CI = -3.43 to -0.38, p = 0.01, Respectively). However, there was not any difference between patients with RAS and healthy controls in erythrocyte Catalase (SMD = - 0.71, 95%CI = -1.56-0.14, p = 0.10). The total antioxidant status (TAS) level, in serum was significantly lower in patients than healthy controls (SMD = - 0.98, 95%CI = -1.57 to -0.39, p = 0.001). In addition, RAS patients had higher levels of serum Malondialdehyde (MDA), Serum total oxidant status, and serum oxidative stress index than healthy controls (SMD = 2.11, 95%CI = 1.43-2.79, p 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-023-03636-1