Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms

Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patients with s...

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Bibliographic Details
Published in:Scientific reports 2018-04, Vol.8 (1), p.6440-7, Article 6440
Main Authors: Duan, Zhihui, Li, Yuanhui, Guan, Sheng, Ma, Congmin, Han, Yuezhen, Ren, Xiangyang, Wei, Liping, Li, Wenbo, Lou, Jiyu, Yang, Zhiyuan
Format: Article
Language:English
Subjects:
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Aneurysm
Aneurysms
Humanities and Social Sciences
Morphology
multidisciplinary
Regression analysis
Risk factors
Rupture
Science
Science (multidisciplinary)
Statistical analysis
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Summary:Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patients with single SIAs (128 ruptured, 135 unruptured) were included, and six morphological parameters, including size, aspect ratio (AR), size ratio (SR), height–width ratio (H/W), flow angle (FA) and aneurysm width–parent artery diameter ratio, and the aneurysm locations were evaluated using three-dimensional geometry, and were used to identify a correlation with aneurysm rupture. Statistically significant differences were observed between ruptured and unruptured groups for AR, SR, H/W, FA, and aneurysm locations, from univariate analyses. Logistic regression analysis further revealed that AR ( p  = 0.034), SR ( p  = 0.004), H/W ( p  = 0.003), and FA ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24732-1