Soluble interleukin-2 receptor levels on admission associated with mortality in coronavirus disease 2019

•Levels of soluble interleukin 2 receptor (sIL2R) >1060 U/ml were significantly associated with mortality on multivariate analysis.•SIL2R offers a marker of cytokine release syndrome and immune overreaction against COVID-19.•Sequential monitoring of sIL2R reflects disease severity. Early and simp...

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Bibliographic Details
Published in:International journal of infectious diseases 2021-04, Vol.105, p.522-524
Main Authors: Kaya, Hiroyasu, Kaji, Masahide, Usuda, Daisuke
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - analysis
COVID-19
COVID-19 - immunology
COVID-19 - mortality
Female
Humans
Logistic Models
Male
Middle Aged
Outcome
Predictor
Receptors, Interleukin-2 - analysis
Retrospective Studies
SARS-CoV-2
Short Communication
SIL2 receptor
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Summary:•Levels of soluble interleukin 2 receptor (sIL2R) >1060 U/ml were significantly associated with mortality on multivariate analysis.•SIL2R offers a marker of cytokine release syndrome and immune overreaction against COVID-19.•Sequential monitoring of sIL2R reflects disease severity. Early and simple detection of high-risk groups is crucial for minimizing severe coronavirus disease 2019 (COVID-19)-related deaths. Soluble interleukin 2 receptors (sIL2R) have been suspected as being prognostic markers for infectious diseases. This study validated the usefulness of sIL2R as a marker for deaths related to COVID-19. This retrospective observational study enrolled participants who showed positive results for severe acute respiratory syndrome coronavirus 2 RNA admitted to the current hospital between 01 April and 30 September 2020. Of the 102 patients enrolled in this study, sIL2R levels were measured in 87 patients. For comparisons between survival and non-survival groups, potential confounding variables were entered into univariate models, and variables showing significant correlations (p 
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2021.03.011