Corneal Epithelial Thickness Changes After Topical Treatment of Dry Eye Disease in Primary Sjögren Syndrome

To evaluate the changes on epithelial thickness before and after topical treatment in primary Sjögren syndrome-associated dry eye disease (SS-DED). This was a prospective study that included referred women with SS-DED and healthy age-matched controls. Corneal epithelial thickness was evaluated using...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2023-04, Vol.17, p.993-1005
Main Authors: Loureiro, Tomas, Rodrigues-Barros, Sandra, Carreira, Ana Rita, Gouveia-Moraes, Filipe, Carreira, Pedro, Vide Escada, Ana, Campos, Paul, Machado, Ines, Campos, Nuno, Ambrosio, Jr, Renato, Archer, Timothy J, Reinstein, Dan Z
Format: Article
Language:English
Subjects:
as-oct
Care and treatment
dry eye disease
epithelial thickness
Eye diseases
Hyaluronic acid
Original Research
sjögren syndrome
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Summary:To evaluate the changes on epithelial thickness before and after topical treatment in primary Sjögren syndrome-associated dry eye disease (SS-DED). This was a prospective study that included referred women with SS-DED and healthy age-matched controls. Corneal epithelial thickness was evaluated using high-definition anterior segment optical coherence tomography (Cirrus 5000 HD-OCT) in the baseline first consultation, and four weeks after treatment with preservative free 1mg/1mL sodium hyaluronate. Schirmer test 1 (ST1), tear break-up time (TBUT), tear meniscus height (TMH), SICCA Ocular Surface Score (SICCA OSS) and Ocular Surface Disease Index (OSDI) were evaluated. Statistical significance was defined as p-value
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S375505