Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. We studied participants of Helsinki Birth Cohort Study born in 1934-1944 (HBCS1934-1944, n = 1277...

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Bibliographic Details
Published in:BMC public health 2020-05, Vol.20 (1), p.708-708, Article 708
Main Authors: Lowry, Estelle, Rautio, Nina, Wasenius, Niko, Bond, Tom A, Lahti, Jari, Tzoulaki, Ioanna, Dehghan, Abbas, Heiskala, Anni, Ala-Mursula, Leena, Miettunen, Jouko, Eriksson, Johan, Järvelin, Marjo-Riitta, Sebert, Sylvain
Format: Article
Language:English
Subjects:
Adults
Age
Aged
Aged, 80 and over
Analysis
Attitudes
Births
Body composition
Body Height
Body mass
Body Mass Index
Body mass index (BMI)
Body size
Body weight
Child welfare
Cohort Studies
Early life
Economic analysis
Economic factors
Exposure
Factor analysis
Female
Finland
Genetic Predisposition to Disease - epidemiology
Genetic research
Genetics
Higher education
Humans
Indexes
Life events
Linear Models
Male
Maternal
Mothers
Obesity
Obesity - epidemiology
Parent educational background
Polygenic risk score for BMI
Pregnancy
Public health
Regression analysis
Risk Factors
Social Class
Social disadvantage
Social mobility
Socioeconomic Factors
Upward mobility
Variables
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Summary:The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. We studied participants of Helsinki Birth Cohort Study born in 1934-1944 (HBCS1934-1944, n = 1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n = 5807, NFBC1986, n = 6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62 years in HBCS1934-1944, at 46 years in NFBC1966 and at 16 years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex. The association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (β = 0.79, 95% CI, 0.33, 1.25, p 
ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-020-08763-w