A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury

• Published in: Respiratory research 2004-11, Vol.5 (1), p.22-22, Article 22
• Main Authors: Funk, Duane J, Graham, M Ruth, Girling, Linda G, Thliveris, James A, McManus, Bruce M, Walker, Elizabeth K Y, Rector, Edward S, Hillier, Craig, Scott, J Elliott, Mutch, W Alan C
• Format: Article
• Language: English
• Subjects: Acute Disease; Analysis; Animals; Disease Models, Animal; Feedback; Interleukins; Lung diseases; Lung Diseases - chemically induced; Lung Diseases - diagnosis; Lung Diseases - physiopathology; Lung Diseases - therapy; Monounsaturated fatty acids; Oleic Acid; Physiological aspects; Positive-Pressure Respiration - methods; Pulmonary Gas Exchange; Respiration, Artificial - methods; Respiratory Mechanics; Surface active agents; Swine; Therapy, Computer-Assisted - methods; Tidal Volume; Treatment Outcome
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/1465-9921-5-22

Biologically variable ventilation (return of physiological variability in rate and tidal volume using a computer-controller) was compared to control mode ventilation with and without a recruitment manoeuvre - 40 cm H2O for 40 sec performed hourly; in a porcine oleic acid acute lung injury model. We compared gas exchange, respiratory mechanics, and measured bronchoalveolar fluid for inflammatory cytokines, cell counts and surfactant function. Lung injury was scored by light microscopy. Pigs received mechanical ventilation (FIO2 = 0.3; PEEP 5 cm H2O) in control mode until PaO2 decreased to 60 mm Hg with oleic acid infusion (PaO2/FIO2