Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity

Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-09, Vol.29 (18), p.4308
Main Authors: Dinić, Jelena, Podolski-Renić, Ana, Novaković, Miroslav, Li, Liang, Opsenica, Igor, Pešić, Milica
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Brain cancer
Cancer
Cancer therapies
Care and treatment
Cells
Chemotherapy
Drug dosages
Drug resistance
Drug Resistance, Multiple - drug effects
Drug Resistance, Neoplasm - drug effects
Enzymes
Glioma
Glycoproteins
Health aspects
Humans
Kinases
Leukemia
Metabolism
multidrug resistance
natural product derivatives
natural products
Neoplasms - drug therapy
Neoplasms - metabolism
P-glycoprotein
Phosphorylation
Physiology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Proteins
Review
Serbia
Toxicity
Transcription factors
Tumors
Vincristine
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Summary:Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in addressing multidrug resistance in cancer therapy. Additionally, we discuss the modulation of P-gp activity by 55 natural product drugs, including derivatives for some of them, based on our team's research findings since 2011. Specifically, we prospect into sesquiterpenoids from the genera , , , , , and ; diterpenoids from the genera and ; chalcones from the genera , , , , and ; riccardins from the genera , , , , and ; and diarylheptanoids from the genera and . Through comprehensive analysis, we aim to highlight the potential of natural products mainly identified in plants from Serbia in influencing P-gp activity and overcoming drug resistance in cancer therapy, while also providing insights into future perspectives in this field.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29184308