Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

Matrix metalloproteinase-9 ( ) polymorphisms, C-1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of polymorphisms in Iranian MS patients is studie...

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Bibliographic Details
Published in:Iranian journal of public health 2019-09, Vol.48 (9), p.1697-1703
Main Authors: Sabbagh, Sima, Nadeali, Zakiye, Dehghani, Leila, Shaygannejad, Vahid, Rezvani, Majid, Saboori, Masih, Ganji, Hamid, Tahani, Soheil, Dehghani, Farzaneh, Hosseinzadeh, Saman, Marzbani, Elnaz, Shafiei, Peiman
Format: Article
Language:English
Subjects:
Alleles
Association study
Gelatinase B
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
MMP-9 gene
Multiple sclerosis
Original
Polymorphism
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Summary:Matrix metalloproteinase-9 ( ) polymorphisms, C-1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of polymorphisms in Iranian MS patients is studied. Association of mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. -1562 T allele of was associated with increased MS risk. However, we found no overall significant effect of -90 (CA)n repeat on MS susceptibility. For as much as molecule is a potential target for MS therapy, to determine whether any of polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.
ISSN:2251-6085
2251-6093
DOI:10.18502/ijph.v48i9.3030