CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy

We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi . We observed an association between the T- genotype (absence of allele -260T) related to l...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2020-01, Vol.115, p.e200110-e200110
Main Authors: Costa, Germano Carneiro, Rocha, Manoel Otávio da Costa, Souza, Paulo Eduardo Alencar de, Melo, Diego Felipe SA, Moreira, Paula Rocha, Gollob, Kenneth John, Nunes, Maria do Carmo Pereira, Dutra, Walderez Ornelas
Format: Article
Language:English
Subjects:
CD14
Chagas cardiomyopathy
PARASITOLOGY
polymorphism
Short Communication
TROPICAL MEDICINE
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Summary:We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi . We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi -induced inflammatory profile of CD14- monocytes.
ISSN:0074-0276
1678-8060
1678-8060
DOI:10.1590/0074-02760200110