The association between lymphogranuloma venereum and HIV among men who have sex with men: systematic review and meta-analysis

Lymphogranuloma venereum (LGV) is an important re-emerging sexually transmitted infection which is reported to affect particularly HIV-positive men who have sex with men (MSM). The aim of this study is to quantify the association between LGV and HIV in the context of the current emergence of LGV. A...

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Bibliographic Details
Published in:BMC infectious diseases 2011-03, Vol.11 (1), p.70-70, Article 70
Main Authors: Rönn, Minttu M, Ward, Helen
Format: Article
Language:English
Subjects:
Chlamydia
Chlamydia infections
Comorbidity
Demographic aspects
Disease transmission
Distribution
Epidemics
Epidemiology
Hepatitis
HIV
HIV infection
HIV Infections - epidemiology
Homosexuality, Male
Human immunodeficiency virus
Humans
Infections
Lymphogranuloma Venereum - epidemiology
Male
Prevalence
Public health
Sexually transmitted diseases
STD
Systematic review
Ulcers
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Summary:Lymphogranuloma venereum (LGV) is an important re-emerging sexually transmitted infection which is reported to affect particularly HIV-positive men who have sex with men (MSM). The aim of this study is to quantify the association between LGV and HIV in the context of the current emergence of LGV. A systematic review was performed on the emergence of LGV among MSM since 2000. We report the prevalence of HIV infection from descriptive studies of MSM with LGV, and conduct a meta-analysis to produce a summary estimate of the association between LGV and HIV from case-control studies where cases were MSM with LGV and controls were MSM with rectal chlamydia caused by non-LGV serovars. The prevalence of HIV among LGV cases ranges from 67% to 100% in 13 descriptive studies. There is a significant association between HIV and LGV (odds ratio 8.19, 95% CI 4.68-14.33). HIV-positive MSM are disproportionately affected by LGV highlighting the importance of prevention efforts to be targeted to this group. Further research is needed to determine whether the association is due to biological or behavioural factors.
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-11-70