3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery

Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applic...

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Bibliographic Details
Published in:Pharmaceutics 2021-08, Vol.13 (9), p.1373
Main Authors: Gao, Ge, Ahn, Minjun, Cho, Won-Woo, Kim, Byoung-Soo, Cho, Dong-Woo
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Automation
Brain cancer
Candidates
Clinical trials
Disease
disease modeling
drug delivery
Drug delivery systems
Drug dosages
drug screening
drug testing
Fibroblasts
Hypoxia
Metabolism
pharmaceutical application
Pharmaceutical industry
Pharmacokinetics
Precision medicine
Review
Toxicology
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Summary:Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applications, enabling the development of customized drug screening and drug delivery systems for individual patients, breaking away from conventional approaches that primarily rely on transgenic animal experiments and mass production. This review provides an extensive overview of 3D printing research applied to drug screening and drug delivery systems that represent pharmaceutical applications. We classify several elements required by each application for advanced pharmaceutical techniques and briefly describe state-of-the-art 3D printing technology consisting of cells, bioinks, and printing strategies that satisfy requirements. Furthermore, we discuss the limitations of traditional approaches by providing concrete examples of drug screening (organoid, organ-on-a-chip, and tissue/organ equivalent) and drug delivery systems (oral/vaginal/rectal and transdermal/surgical drug delivery), followed by the introduction of recent pharmaceutical investigations using 3D printing-based strategies to overcome these challenges.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13091373