IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity

Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhib...

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Bibliographic Details
Published in:Scientific reports 2017-06, Vol.7 (1), p.3451-11, Article 3451
Main Authors: Pearson, Mark J., Herndler-Brandstetter, Dietmar, Tariq, Mohammad A., Nicholson, Thomas A., Philp, Ashleigh M., Smith, Hannah L., Davis, Edward T., Jones, Simon W., Lord, Janet M.
Format: Article
Language:English
Subjects:
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Adipose tissue
Aged
Arthritis
Body Mass Index
Cell Communication
Chondrocytes
Chondrocytes - metabolism
Cytokines
Female
Fibroblasts
Fibroblasts - metabolism
Hip
Humanities and Social Sciences
Humans
Inflammation
Interleukin 6
Interleukin-6 - biosynthesis
Interleukin-8 - metabolism
Leptin
Leptin - metabolism
Lymphocytes
Male
Middle Aged
Models, Biological
multidisciplinary
Obesity
Obesity - complications
Osteoarthritis
Osteoarthritis - complications
Osteoarthritis - metabolism
Osteoarthritis - pathology
Peripheral blood
Science
Science (multidisciplinary)
Synovial fluid
Synovial Fluid - metabolism
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. No differences in either peripheral blood or local lymphocyte populations were found between obese and normal-weight hip OA patients. However, synovial fibroblasts from obese OA patients were found to secrete greater amounts of the pro-inflammatory cytokine IL-6, compared to those from normal-weight patients (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-03759-w