Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study

Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interac...

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Bibliographic Details
Published in:Journal of Obesity 2011-01, Vol.2011 (2011), p.234-241
Main Authors: Benjamin, Ashlee M., Suchindran, Sunil, Pearce, Kaela, Rowell, Jennifer, Lien, Lillian F., Guyton, John R., McCarthy, Jeanette J.
Format: Article
Language:English
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Summary:Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.
ISSN:2090-0708
2090-0716
DOI:10.1155/2011/329038