The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study

Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of pa...

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Published in:Frontiers in oncology 2024-05, Vol.14, p.1349536-1349536
Main Authors: Karwacki, Jakub, Łątkowska, Małgorzata, Jarocki, Michał, Jaworski, Arkadiusz, Szuba, Przemysław, Poterek, Adrian, Lemiński, Artur, Kaczmarek, Krystian, Hałoń, Agnieszka, Szydełko, Tomasz, Małkiewicz, Bartosz
Format: Article
Language:English
Subjects:
histopathological examination
lymphovascular invasion
oncologic staging
Oncology
prognostic factors
prostate cancer
radical prostatectomy
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Summary:Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of patients prone to LVI during postoperative examination; and secondly, to assess postoperative outcomes correlated with LVI. We retrospectively analyzed 861 nonmetastatic PCa patients who underwent radical prostatectomy (RP), investigating preoperative factors and postoperative outcomes. Surgical specimens were processed following established guidelines. Statistical analyses utilized non-parametric tests to assess the association between LVI and both pre- and postoperative factors. Furthermore, logistic regression analyses were utilized to develop models aimed at identifying the most significant predictors of LVI and pN1 status, respectively. Numerous preoperative factors exhibited significant correlations with LVI, offering valuable clinical insights. Logistic regression identified magnetic resonance imaging (MRI)-based clinical tumor stage (cT) 3-4, biopsy Gleason Grading Group (GGG) 3-5, preoperative prostate specific antigen (PSA) ≥20 and percentage of positive biopsy cores (PPBC) ≥50% as the strongest preoperative predictors of LVI. Additionally, the study uncovered an association between LVI and postoperative outcomes, including postoperative PSA ( value
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1349536