Essential role of local antibody distribution in mediating bone-resorbing effects

The link between antibodies and bone mass is debated. Activated IgG, which interacts directly with Fc gamma receptors, stimulates osteoclastogenesis in vitro, and local injection in immune-activated mice leads to bone loss. Multiple myeloma patients with high serum IgG levels have induced osteoclast...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.5684-5684, Article 5684
Main Authors: Nurkkala-Karlsson, Merja, Lagerquist, Marie K., Gupta, Priti, Ohlsson, Claes, Mellström, Dan, Engdahl, Cecilia
Format: Article
Language:English
Subjects:
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Animals
Anti-Citrullinated Protein Antibodies
Antibodies
Arthritis
Arthritis, Rheumatoid - metabolism
Autoantibodies
Autoimmune diseases
Bone density
Bone loss
Bone mass
Bone mineral density
Cancellous bone
Citrulline
Endocrinology and Diabetes
Endokrinologi och diabetes
Fc receptors
Humanities and Social Sciences
Humans
IgG
Immunoglobulin G
Injection
Male
metabolism
Mice
multidisciplinary
Multiple myeloma
Osteoclastogenesis
Receptors
Receptors, IgG - metabolism
Rheumatoid
Rheumatoid arthritis
Science
Science (multidisciplinary)
Serum levels
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Summary:The link between antibodies and bone mass is debated. Activated IgG, which interacts directly with Fc gamma receptors, stimulates osteoclastogenesis in vitro, and local injection in immune-activated mice leads to bone loss. Multiple myeloma patients with high serum IgG levels have induced osteoclast activation and display bone loss. In addition, bone loss has been linked to serum autoantibodies in autoimmune diseases, including anti-citrullinated protein antibodies (ACPA) in individuals with rheumatoid arthritis (RA). Whether serum IgG or autoantibodies regulate bone mass under healthy conditions is poorly studied. In elderly men, neither serum levels of polyclonal IgG nor autoantibody were associated with areal bone mineral density in the MrOS Sweden study. Repetitive systemic injections of high-dose polyclonal IgG complexes in mice did not exert any discernible impact on bone mineral density. However, repetitive local intra-articular injection of the same IgG complexes led to a localized reduction of trabecular bone density. These results indicate antibodies may only impact bone density when close to the bone, such as within the synovial joint.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-56192-1