U0126 Compound Triggers Thermogenic Differentiation in Preadipocytes via ERK-AMPK Signaling Axis

In recent years, thermogenic differentiation and activation in brown and white adipose tissues have been regarded as one of the major innovative and promising strategies for the treatment and amelioration of obesity. However, the pharmacological approach towards this process has had limited and insu...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (9), p.7987
Main Authors: Onikanni, Sunday Amos, Yang, Cheng-Ying, Noriega, Lloyd, Wang, Chih-Hao
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes, Brown - metabolism
Adipogenesis
Adipose tissue
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Adipose tissues
Adrenergic receptors
Adults
AMP-Activated Protein Kinases - metabolism
Biosynthesis
Body fat
Cardiovascular disease
Cell Differentiation
Differentiation
Drug discovery
Drug dosages
Energy expenditure
Fatty acids
Gene expression
Genes
Genetic aspects
Humans
Investigations
Kinases
MEK inhibition
Mitochondria
Obesity
Obesity - drug therapy
Overweight
Pharmacology
Preadipocytes
Proteins
Signal Transduction
Thermogenesis
Type 2 diabetes
U0126
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Summary:In recent years, thermogenic differentiation and activation in brown and white adipose tissues have been regarded as one of the major innovative and promising strategies for the treatment and amelioration of obesity. However, the pharmacological approach towards this process has had limited and insufficient commitments, which presents a greater challenge for obesity treatment. This research evaluates the effects of U0126 compound on the activation of thermogenic differentiation during adipogenesis. The results show that U0126 pretreatment primes both white and brown preadipocytes to upregulate thermogenic and mitochondrial genes as well as enhance functions during the differentiation process. We establish that U0126-mediated thermogenic differentiation induction occurs partially via AMPK activation signaling. The findings of this research suggest U0126 as a promising alternative ligand in pursuit of a pharmacological option to increase thermogenic adipocyte formation and improve energy expenditure. Thus it could pave the way for the discovery of therapeutic drugs for the treatment of obesity and its related complications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097987