Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism

Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect of LH and FSH deficiency on semen. Twenty-five diagnosed p...

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Bibliographic Details
Published in:Heliyon 2023-04, Vol.9 (4), p.e14779-e14779, Article e14779
Main Authors: Li, Xiaogang, Guo, Ye, Wang, Xi, Li, Haolong, Mao, Jiangfeng, Yan, Songxin, Luo, Guoju, Wang, Renzhi, Wu, Xueyan, Li, Yongzhe
Format: Article
Language:English
Subjects:
Lipidomics
Metabolomics
Normosmic congenital hypogonadotropic hypogonadism
Rare disease
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Summary:Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect of LH and FSH deficiency on semen. Twenty-five diagnosed patients with nCHH (HH group) and twenty-three healthy participants (HC group) were enrolled. Laboratory parameters, seminal plasma samples and patients’ medical data were collected. Untargeted metabolomics and lipidomic profiling were performed using mass spectrometry (MS). The metabolomics profiling are altered among patients with nCHH and healthy controls. There are 160 kinds of differential metabolites and the main different lipid species are TAG, PC, SM and PE. The metabolomics profiles in patients with nCHH changed. We hope that this work provides important insights into the pathophysiology of nCHH.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e14779