miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study

The underlying mechanisms of rituximab action remain incompletely understood in chronic lymphocytic leukemia. Recent data suggest that circulating micro-ribonucleic acids correlate with chronic lymphocytic leukemia progression and response to rituximab. Our study aimed at identifying circulating mic...

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Bibliographic Details
Published in:Haematologica (Roma) 2017-04, Vol.102 (4), p.746-754
Main Authors: Gagez, Anne-Laure, Duroux-Richard, Isabelle, Leprêtre, Stéphane, Orsini-Piocelle, Frédérique, Letestu, Rémi, De Guibert, Sophie, Tuaillon, Edouard, Leblond, Véronique, Khalifa, Olfa, Gouilleux-Gruart, Valérie, Banos, Anne, Tournilhac, Olivier, Dupuis, Jehan, Jorgensen, Christian, Cartron, Guillaume, Apparailly, Florence
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor
Cancer
Cluster Analysis
Diagnosis, Differential
Female
Gene Expression Regulation, Leukemic
Genotype
Hematology
Human health and pathology
Humans
Immunology
Immunotherapy
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Life Sciences
Lymphocyte Depletion
Lymphocytosis - diagnosis
Lymphocytosis - genetics
Male
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Models, Biological
Prognosis
Rituximab - administration & dosage
RNA Interference
Transcriptome
Treatment Outcome
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Summary:The underlying mechanisms of rituximab action remain incompletely understood in chronic lymphocytic leukemia. Recent data suggest that circulating micro-ribonucleic acids correlate with chronic lymphocytic leukemia progression and response to rituximab. Our study aimed at identifying circulating micro-ribonucleic acids that predict response to rituximab monotherapy in chronic lymphocytic leukemia patients. Using a hierarchical clustering of micro-ribonucleic acid expression profiles discriminating 10 untreated patients with low or high lymphocyte counts, we found 26 micro-ribonucleic acids significantly deregulated. Using individual real-time reverse transcription polymerase chain reaction, the expression levels of micro-ribonucleic acids representative of these two clusters were further validated in a larger cohort (n=61). MiR-125b and miR-532-3p were inversely correlated with rituximab-induced lymphodepletion ( =0.020 and =0.001, respectively) and with the CD20 expression on CD19 cells ( =0.0007 and
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2016.153189