Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the de...

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Bibliographic Details
Published in:Pulmonary circulation 2018-07, Vol.8 (3), p.1-4
Main Authors: Huang, Yadi, Boerema-de Munck, Anne, Buscop-van Kempen, Marjon, Sluiter, Ilona, de Krijger, Ronald, Tibboel, Dick, Rottier, Robbert J.
Format: Article
Language:English
Subjects:
Hernias
Hypoxia
hypoxia inducible factor
Pulmonary hypertension
pulmonary vascular development and epithelium
Research Letter
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Summary:We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045894018783734