Spatial Distribution of Drug-Resistant Mycobacterium tuberculosis Infections in Rural Eastern Cape Province of South Africa

Tuberculosis (TB), an infectious airborne disease caused by (Mtb), is a serious public health threat reported as the leading cause of morbidity and mortality worldwide. South Africa is a high-TB-burden country with TB being the highest infectious disease killer. This study investigated the distribut...

Full description

Saved in:
Bibliographic Details
Published in:Pathogens (Basel) 2023-03, Vol.12 (3), p.475
Main Authors: Faye, Lindiwe M, Hosu, Mojisola C, Vasaikar, Sandeep, Dippenaar, Anzaan, Oostvogels, Selien, Warren, Rob M, Apalata, Teke
Format: Article
Language:English
Subjects:
China
Drug resistance
Gene mapping
Genes
Geographic information systems
Geography
Health care
Health care facilities
Health facilities
Health risks
health services
heteroresistance
Infectious diseases
Laboratories
Morbidity
mortality
Mutation
mutations
Mycobacterium tuberculosis
Public health
RpoB protein
South Africa
Spatial analysis
Spatial distribution
spoligotypes
Spoligotyping
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tuberculosis (TB), an infectious airborne disease caused by (Mtb), is a serious public health threat reported as the leading cause of morbidity and mortality worldwide. South Africa is a high-TB-burden country with TB being the highest infectious disease killer. This study investigated the distribution of Mtb mutations and spoligotypes in rural Eastern Cape Province. The Mtb isolates included were 1157 from DR-TB patients and analysed by LPA followed by spoligotyping of 441 isolates. The distribution of mutations and spoligotypes was done by spatial analysis. The gene had the highest number of mutations. The distribution of and mutations was more prevalent in four healthcare facilities, mutations were more prevalent in three healthcare facilities, and heteroresistant isolates were more prevalent in five healthcare facilities. The Mtb was genetically diverse with Beijing more prevalent and largely distributed. Spatial analysis and mapping of gene mutations and spoligotypes revealed a better picture of distribution.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12030475