Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity

• Published in: Molecules (Basel, Switzerland) Switzerland), 2018-08, Vol.23 (8), p.1952
• Main Authors: Aguilar-Guadarrama, A Berenice, Rios, María Yolanda
• Format: Article
• Language: English
• Subjects: Alcohol; Alcohols; aromatic compounds; Bark; carotenoids; Cochlospermaceae; Cochlospermum vitifolium; Dihydroxybenzoic acid; Ferulic acid; Flavonoids; Gentisic acid; Hepatitis; Hepatitis C; Herbal medicine; Jaundice; Kaempferol; Lignans; Liver; liver activity; Naringenin; Sterols
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23081952

The sterols β-sitostenone ( ), stigmast-4,6,8(14),22-tetraen-3-one ( ), β-sitosterol ( ) and stigmasterol ( ), the aromatic derivatives antiarol ( ) and gentisic acid ( ), the phenylpropanes coniferyl alcohol ( ), epoxyconiferyl alcohol ( ) and ferulic acid ( ), the apocarotenoid vomifoliol ( ), the flavonoids naringenin ( ), 7,4'-dimethoxytaxifolin (7,4'-dimethoxydihydroquercetin, ), aromadendrin ( ), kaempferol ( ), taxifolin (dihydroquercetin, ), prunin (naringenin-7- -β-d-glucoside, ), populnin (kaempferol-7- -β-d-glucoside, ) and senecin (aromadendrin-7- -β-d-glucoside, ) and the lignans kobusin ( ) and pinoresinol ( ), were isolated from the dried bark of Spreng (Cochlospermaceae), a Mexican medicinal plant used to treat jaundice, liver ailments and hepatitis C. Fourteen of these compounds were isolated for the first time from this plant and from the genus. Compounds ⁻ , ⁻ , ⁻ , ⁻ and have previously exhibited diverse beneficial liver activities. The presence of these compounds in correlates with the use of this Mexican medicinal plant.