Composition of cardiac troponin release differs after marathon running and myocardial infarction

Elevations of cardiac troponin T (cTnT) levels are common after strenuous exercise. We assessed whether the composition of cTnT release after marathon race differs from that of acute myocardial infarction (MI). Troponin composition was analysed in plasma samples taken from 45 runners after marathon...

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Bibliographic Details
Published in:Open heart 2024-11, Vol.11 (2), p.e002954
Main Authors: Airaksinen, K E Juhani, Paana, Tuomas, Vasankari, Tuija, Salonen, Selma, Tuominen, Tuulia, Linko-Parvinen, Anna, Pallari, Hanna-Mari, Hellman, Tapio, Teppo, Konsta, Heinonen, Olli J, Jaakkola, Samuli, Wittfooth, Saara
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Coronary Artery Disease
Female
Humans
Male
Marathon Running - physiology
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Original Research
Running - physiology
Time Factors
Troponin T - blood
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Summary:Elevations of cardiac troponin T (cTnT) levels are common after strenuous exercise. We assessed whether the composition of cTnT release after marathon race differs from that of acute myocardial infarction (MI). Troponin composition was analysed in plasma samples taken from 45 runners after marathon race and from 84 patients with type 1 MI. The concentration of long cTnT (intact and mildly fragmented cTnT) was measured with a novel upconversion luminescence immunoassay, total cTnT with a commercial high-sensitivity cTnT assay, and the ratio of long to total cTnT (troponin ratio) was determined as a measure of troponin fragmentation. Total cTnT exceeded the upper reference limit (>14 ng/L) in 37 (82%) runners. Troponin ratio was lower in runners ((IQR) 0.17 (0.11-0.24) vs 0.62 (0.29-0.96), p
ISSN:2053-3624
2053-3624
DOI:10.1136/openhrt-2024-002954