A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment

The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need. To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for v...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2020-08, Vol.7, p.186
Main Authors: Pirone, Luciano, Del Gatto, Annarita, Di Gaetano, Sonia, Saviano, Michele, Capasso, Domenica, Zaccaro, Laura, Pedone, Emilia
Format: Article
Language:English
Subjects:
ACE2
galectin
ganglioside
integrin
Molecular Biosciences
spike protein
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Summary:The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need. To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics. Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here. One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2020.00186