A Cross-Talk about Radioresistance in Lung Cancer-How to Improve Radiosensitivity According to Chinese Medicine and Medicaments That Commonly Occur in Pharmacies

• Published in: International journal of molecular sciences 2023-07, Vol.24 (13), p.11206
• Main Authors: Nowak, Paulina, Bil-Lula, Iwona, Śliwińska-Mossoń, Mariola
• Format: Article
• Language: English
• Subjects: Apoptosis; Apoptosis - radiation effects; Biomarkers; Cancer; Cancer therapies; Care and treatment; Cell Line, Tumor; Chinese medicine; Cytotoxicity; Drug development; Drugs; Drugstores; Epidemiology; Genes; Genetic aspects; Genotoxicity; Humans; Ionizing radiation; Kinases; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Medical prognosis; Medicine, Chinese Traditional; Medicine, Oriental; Metastasis; Methods; Morphology; Mutation; Pharmacies; Pharmacy; Phenotypes; Radiation therapy; Radiation tolerance; Radiation Tolerance - radiation effects; Radiation, Ionizing; Radioresistance; Radiosensitivity; Radiotherapy; Respiratory agents; Review; Stem cells; traditional Chinese medicine; Tumors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241311206

Lung cancer is one of the most common cancers in the population and is characterized by non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological treatment. Due to the difficult placement of the tumor, one of the main methods of lung cancer treatment is radiotherapy, which damages the DNA of cancer cells, inducing their apoptosis. However, resistance to ionizing radiation may develop during radiotherapy cycles, leading to an increase in the number of DNA points of control that protect cells from apoptosis. Cancer stem cells are essential for radioresistance, and due to their ability to undergo epithelial-mesenchymal transition, they modify the phenotype, bypassing the genotoxic effect of radiotherapy. It is therefore necessary to search for new methods that could improve the cytotoxic effect of cells through new mechanisms of action. Chinese medicine, with several thousand years of tradition, offers a wide range of possibilities in the search for compounds that could be used in conventional medicine. This review introduces the potential candidates that may present a radiosensitizing effect on lung cancer cells, breaking their radioresistance. Additionally, it includes candidates taken from conventional medicine-drugs commonly available in pharmacies, which may also be significant candidates.