Chronic lymphocytic leukemia and JAK2 V617F positive essential thrombocythemia: Distinct clonal diseases?

The  coexistence  of  myeloproliferative  neoplasia  (MPN)  and  chronic  lymphocytic  leukemia  (CLL)  is  a  rare  entity.  The  underlying  pathogenetic  mechanism  of  this  association  is  unknown.  Here,  we  present  a  case  who  had  JAK2  V617F  mutation  positive  essential  thrombocythe...

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Bibliographic Details
Published in:Mediterranean journal of hematology and infectious diseases 2014-08, Vol.1
Main Authors: Deniz Çetin, İrfan Yavaşoğlu, Gürhan Kadıköylü, Gökay Bozkurt, Zahit Bolaman
Format: Article
Language:English
Subjects:
chronic lymphocytic leukemia
essential thrombocythemia
JAK2 mutation
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Summary:The  coexistence  of  myeloproliferative  neoplasia  (MPN)  and  chronic  lymphocytic  leukemia  (CLL)  is  a  rare  entity.  The  underlying  pathogenetic  mechanism  of  this  association  is  unknown.  Here,  we  present  a  case  who  had  JAK2  V617F  mutation  positive  essential  thrombocythemia  (ET)  and  CLL  simultaneously.  In  our  patient,  we  did  not  detect  JAK2  V617F  mutation  in  lymphoid  lineage  cells.  This  situation  reduces  the  possibility  of  a  common  initiative  pluripotent  stem  cell  theory  for  these  two  distinct  clonal  haematological  diseases.  It  is  likely  that  the  association  between  CLL  and  ET  is  coincidental.
ISSN:2035-3006