A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China

We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bi...

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Bibliographic Details
Published in:Frontiers in neurology 2019-06, Vol.10, p.534
Main Authors: Yang, HongNa, Han, Hui, Wang, Hao, Cui, Yi, Liu, Han, Ding, ShiFang
Format: Article
Language:English
Subjects:
herpes simplex encephalitis
Japanese encephalitis
Neurology
next-generation sequencing
pseudorabies virus
viral encephalitis
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Summary:We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2019.00534