Doxorubicin as a Potential Treatment Option in Canine Mammary Tumors

Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a g...

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Published in:Veterinary sciences 2023-11, Vol.10 (11), p.654
Main Authors: Gherman, Madalina Luciana, Zanoaga, Oana, Budisan, Liviuta, Raduly, Lajos, Berindan-Neagoe, Ioana
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Breast cancer
Cancer
Cancer therapies
canine
Care and treatment
Cell culture
Cell cycle
Cell growth
Cell proliferation
Chemotherapy
Development and progression
DNA damage
Dogs
Doxorubicin
epithelial to mesenchymal transition
Gene expression
Genes
Mammary gland
mammary tumors
Metastasis
Microscopy
Oncology, Experimental
Stains & staining
Stem cells
Tumor cell lines
Tumors
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Summary:Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a good effect in different biological processes like apoptosis, autophagy, the cell cycle, cell invasion, and the epithelial-to-mesenchymal transition. This study followed the effects of Doxorubicin on two canine mammary cancer cell lines P114 and CMT-U27. Doxorubicin treatment in both cell lines shows an inhibitory effect in cell proliferation and an alteration in expression of the EMT-related genes. The obtained results provide valuable information for revealing the link between Doxorubicin, phenotypic changes, and proliferation dynamics in canine mammary tumor models.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci10110654