Antibacterial properties of mesoporous silica coated with cerium oxide nanoparticles in dental resin composite

Cerium oxide nanoparticles are known for their antibacterial effects resulting from Ce 3+ to Ce 4+ conversion. Application of such cerium oxide nanoparticles in dentistry has been previously considered but limited due to deterioration of mechanical properties. Hence, this study aimed to examine meso...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.18014-11, Article 18014
Main Authors: Byun, Sung-Yun, Han, A. Ruem, Kim, Kwang-Mahn, Kwon, Jae-Sung
Format: Article
Language:English
Subjects:
692/700/3032
692/700/3032/3065
692/700/3032/3065/3069
Acrylic Resins - chemistry
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial property
Cerium
Cerium - chemistry
Cerium - pharmacology
Cerium oxide nanoparticle
Cerium oxides
Coatings
Composite materials
Composite Resins - chemistry
Composite Resins - pharmacology
Dental composite resin
Dental restorative materials
Dentistry
Flexural Strength
Humanities and Social Sciences
Materials Testing
MCM-41
Mechanical properties
Mechanical property
Mesoporous silica
multidisciplinary
Nanoparticles
Nanoparticles - chemistry
Polyurethanes - chemistry
Polyurethanes - pharmacology
Porosity
Resins
Science
Science (multidisciplinary)
Silica
Silicon Dioxide - chemistry
Streptococcus mutans - drug effects
Variance analysis
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Summary:Cerium oxide nanoparticles are known for their antibacterial effects resulting from Ce 3+ to Ce 4+ conversion. Application of such cerium oxide nanoparticles in dentistry has been previously considered but limited due to deterioration of mechanical properties. Hence, this study aimed to examine mesoporous silica (MCM-41) coated with cerium oxide nanoparticles and evaluate the antibacterial effects and mechanical properties when applied to dental composite resin. Cerium oxide nanoparticles were coated on the MCM-41 surface using the sol–gel method by adding cerium oxide nanoparticle precursor to the MCM-41 dispersion. The samples were tested for antibacterial activity against Streptococcus mutans via CFU and MTT assays. The mechanical properties were assessed by flexural strength and depth of cure according to ISO 4049. Data were analyzed using a t-test, one-way ANOVA, and Tukey’s post-hoc test ( p  = 0.05). The experimental group showed significantly increased antibacterial properties compared to the control groups ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-69102-2