Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic status of various tissues. Several foods and consumption patterns have been associated with various cancers and approxima...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-07, Vol.18 (7), p.1544
Main Authors: Saha, Subbroto Kumar, Lee, Soo Bin, Won, Jihye, Choi, Hye Yeon, Kim, Kyeongseok, Yang, Gwang-Mo, Dayem, Ahmed Abdal, Cho, Ssang-Goo
Format: Article
Language:English
Subjects:
Animals
cancer progression
Carcinogenesis - chemically induced
Carcinogenesis - metabolism
Homeostasis
Humans
Malnutrition - complications
nutrition
Nutritional Status
Overnutrition - complications
Oxidative Stress
reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Signal Transduction
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Summary:Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic status of various tissues. Several foods and consumption patterns have been associated with various cancers and approximately 30-35% of the cancer cases are correlated with overnutrition or malnutrition. However, several contradictory studies are available regarding the association between diet and cancer risk, which remains to be elucidated. Concurrently, oxidative stress is a crucial factor for cancer progression and therapy. Nutritional oxidative stress may be induced by an imbalance between antioxidant defense and pro-oxidant load due to inadequate or excess nutrient supply. Oxidative stress is a physiological state where high levels of reactive oxygen species (ROS) and free radicals are generated. Several signaling pathways associated with carcinogenesis can additionally control ROS generation and regulate ROS downstream mechanisms, which could have potential implications in anticancer research. Cancer initiation may be modulated by the nutrition-mediated elevation in ROS levels, which can stimulate cancer initiation by triggering DNA mutations, damage, and pro-oncogenic signaling. Therefore, in this review, we have provided an overview of the relationship between nutrition, oxidative stress, and cancer initiation, and evaluated the impact of nutrient-mediated regulation of antioxidant capability against cancer therapy.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18071544