Riddle of the Sphinx: facts and evidence regarding the link between mental stress and tumor occurrence and development

The decrease in BDNF levels under stress state leads to the upregulation of ABCG2 expression and enhanced drug resistance, which cause accelerated growth and metastasis of tumor cells. [...]the decrease of BDNF level under chronic mental stress will promote the disease progression and the formation...

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Bibliographic Details
Published in:Chinese medical journal 2022-12, Vol.135 (24), p.2998-3000
Main Authors: Wang, Ruilin, Yu, Sheng, Yu, Limeng, Wang, Qiming, Wu, Yufeng
Format: Article
Language:English
Subjects:
Cell growth
Correspondence
Hormones
Humans
Insulin-like growth factors
Kinases
Neoplasms - epidemiology
Neoplasms - etiology
Nitric oxide
Stress, Psychological - complications
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Summary:The decrease in BDNF levels under stress state leads to the upregulation of ABCG2 expression and enhanced drug resistance, which cause accelerated growth and metastasis of tumor cells. [...]the decrease of BDNF level under chronic mental stress will promote the disease progression and the formation of drug resistance in tumor patients. Blocking the IGF2/IGF1R pathway by blocking receptor-ligand interactions or limiting kinase activation can inhibit the proliferation and growth of tumor cells and make them sensitive to programmed cell death, so as to inhibit tumor occurrence and development, restore drug sensitivity and improve the prognosis of patients. [...]how to block the IGF2/IGF1R axis will become the important concerns to inhibit tumor cell growth and migration and restore drug sensitivity. There are three different subtypes of nitric oxide synthases (NOSs): endothelial-type nitric oxide synthase, neuronal-type nitric oxide synthase and inducible nitric oxide synthase (iNOS). iNOS overexpression promotes angio-genesis and accelerates tumor cell invasion and progression, which is related to the low survival of tumor patients. Overall, iNOS overexpression and the subsequent increase in NO have broad implications in malignancies. [...]iNOS is a potential target for eliminating the harmful effects of mental stress on tumorigenesis and development.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002129