Meta-analysis highlight the therapeutic potential of stem cells for premature ovarian failure

Stem cell (SC) transplantation has shown potential as a therapeutic approach for premature ovarian failure (POF). Despite this, no quantitative analysis has been conducted on the efficacy of SC therapy for POF in humans. To address this gap, the present study conducted a meta-analysis to evaluate th...

Full description

Saved in:
Bibliographic Details
Published in:Regenerative therapy 2024-06, Vol.26, p.478-488
Main Authors: Umer, Amna, Ahmad, Khalil, Khan, Nasar, Greene, David Lawrence, Shamim, Sabiha, Habiba, Umm E.
Format: Article
Language:English
Subjects:
Cell transplantation
Ovarian function
Premature ovarian failure
Regenerative medicine
Stem cell
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stem cell (SC) transplantation has shown potential as a therapeutic approach for premature ovarian failure (POF). Despite this, no quantitative analysis has been conducted on the efficacy of SC therapy for POF in humans. To address this gap, the present study conducted a meta-analysis to evaluate the effectiveness of the transplantation of SC in improving ovarian function among POF patients. A systematic review in this regard by searching PubMed, ScienceDirect, clinicalTrial.gov, and Cochrane's library databases was conducted to identify relevant studies, while associated reviews were also considered. The extracted data included parameters such as estradiol (E2), follicle-stimulating hormone (FSH), follicle count (FC), ovarian weight (OW), number of pregnancies, and live birth. As per the combined effect taking the last follow-up time, the level of FSH and AMH for the SC group was lower than these were at the baseline as (SMD: 1.58, 95% CI: 0.76 to 3.92, P-value: 0.185 > 0.05, I2: 94.03%) and (SMD: 1.34, 95% CI: 0.77 to 1.92, P-value: 0.001 
ISSN:2352-3204
2352-3204
DOI:10.1016/j.reth.2024.07.001