Molecular Characterisation and Antibody Response to Bovine Respiratory Syncytial Virus in Vaccinated and Infected Cattle in Turkey

Bovine respiratory syncytial virus (BRSV) is one of the most important respiratory pathogens of cattle. In this study, frequency of infection, analysis of variants, and the immune status of vaccinated and non-vaccinated cattle were studied. Blood ( = 162) and nasal/oropharyngeal ( = 277) swabs were...

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Bibliographic Details
Published in:Pathogens (Basel) 2024-04, Vol.13 (4), p.304
Main Authors: Aydin, Ozge, Yilmaz, Aysun, Turan, Nuri, Richt, Juergen A, Yilmaz, Huseyin
Format: Article
Language:English
Subjects:
Abattoirs
Antibodies
antibody
Antibody response
Bacterial infections
Biosecurity
bovine respiratory syncytial virus
Cattle
ELISA
Gene sequencing
Genes
Genomes
Homology
Immune status
Immunization
Infections
Lungs
PCR
phylogenetic
Phylogenetics
Phylogeny
Pneumonia
Proteins
Respiratory diseases
Respiratory syncytial virus
RNA polymerase
Serology
Statistical analysis
Vaccination
Vaccines
Viruses
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Summary:Bovine respiratory syncytial virus (BRSV) is one of the most important respiratory pathogens of cattle. In this study, frequency of infection, analysis of variants, and the immune status of vaccinated and non-vaccinated cattle were studied. Blood ( = 162) and nasal/oropharyngeal ( = 277) swabs were collected from 62 cattle herds in Turkey. Lung samples ( = 37) were also taken from dead animals and abattoirs. Antibodies to BRSV were detected in 76 (46%) out of 162 sera. The antibody levels in the vaccinated and non-vaccinated groups were statistically significant. Among 277 nasal/oropharyngeal swabs and 37 lungs, ten nasal/oropharyngeal and four lung samples were positive for BRSV-RNA. BRSV-G gene sequences of 5 out of 14 RT-PCR positive samples showed that all viruses clustered as Group-III in phylogenetic analysis with 88-100% homology. Similarity with previous Turkish BRSVs was 89-98%, and that with BRSVs detected in the USA and Czechia was 89.47-93.12%. BRSV continues to circulate in Turkish cattle, and vaccination seems beneficial in preventing BRSV. The diversity of the BRSVs found in this study needs be considered in vaccination strategies.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens13040304