Acquired von Willebrand syndrome: focused for hematologists

The acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of inherited von Willebrand disease. However, unlike the inherited disease, AvWS occurs in persons with no personal and family history of bleeding and is often associated with a variety...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2020-08, Vol.105 (8), p.2032-2037
Main Authors: Franchini, Massimo, Mannucci, Pier Mannuccio
Format: Article
Language:English
Subjects:
Cardiovascular Diseases
Hemorrhage - diagnosis
Hemorrhage - etiology
Hemorrhagic Disorders
Humans
Review
Syndrome
von Willebrand Diseases - diagnosis
von Willebrand Diseases - etiology
von Willebrand Diseases - therapy
von Willebrand Factor
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of inherited von Willebrand disease. However, unlike the inherited disease, AvWS occurs in persons with no personal and family history of bleeding and is often associated with a variety of underlying diseases, most frequently lymphoproliferative, myeloproliferative and cardiovascular disorders. After the presentation of a typical case, in this narrative review we discuss the more recent data on the pathophysiology, clinical, laboratory and therapeutic aspects of this acquired bleeding syndrome. We chose to focus particularly on those aspects of greater interest for the hematologist.
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2020.255117