Corchorus olitorius L. ameliorates alcoholic liver disease by regulating gut-liver axis

• Published in: Journal of functional foods 2021-10, Vol.85, p.104648, Article 104648
• Main Authors: Do, Moon Ho, Lee, Hyun Hee L., Kim, Yoonsook, Lee, Hye-Bin, Lee, Eunjung, Park, Jae Ho, Park, Ho-Young
• Format: Article
• Language: English
• Subjects: Alcoholic liver disease; Corchorus olitorius L; Gut microbiota; Inflammation; Lipid metabolism; Molokhia
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2021.104648

[Display omitted] •Water-soluble extract from molokhia leaves (WM) were extracted and characterized.•WM ameliorates alcohol-induced metabolic disorder parameters.•WM ameliorates alcohol-induced inflammation and lipid accumulation in liver.•WM regulates gut microbial composition and ameliorates gut barrier function. Gut microbial dysbiosis, induced by alcohol consumption, disrupts the gut-liver axis, leading to the development and progression of alcoholic liver disease. In this study, we investigated the protective effects of the water-soluble extract from molokhia (Corchorus olitorius L.) leaves (WM) on the alcohol-induced disruption of the gut-liver axis in mice. The administration of 50 and 100 mg/kg WM reduced the levels of serum biomarkers for liver injury. Moreover, WM treatment ameliorated the alcohol-induced increase in hepatic inflammation and lipogenic protein levels. WM improved the gut microbial composition disrupted by alcohol, which suggests the effects of WM in mediating the gut-liver axis. WM also improved gut barrier function via the regulation of gut permeability and tight junction protein expression. These results indicate that WM can be used as a food supplement to improve alcohol-induced liver damage by regulating the gut-liver axis.