The diagnosis and pathogenesis of chronic alcoholic myopathy

Peripheral neuromuscular apparatus lesion is a common complication of chronic alcohol intoxication. Alcohol-induced skeletal muscle diseaseis least studied now. A comprehensive clinical, neurophysiological, and morphological examination was made in 42 patients with chronic alcoholintoxication during...

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Bibliographic Details
Published in:Nervno-myshechnye bolezni 2015-02 (2), p.35-38
Main Authors: Yu. V. Kazantseva, O. E. Zinovyeva, B. S. Shenkman, N. S. Shcheglova, E. A. Lysenko
Format: Article
Language:Russian
Subjects:
alcoholism
atrophy 2 type
electromyography
insulin-like growth factor 1
muscle biopsy
muscle morphometrу
myopathy
protein electrophoresis
protein synthesis
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Summary:Peripheral neuromuscular apparatus lesion is a common complication of chronic alcohol intoxication. Alcohol-induced skeletal muscle diseaseis least studied now. A comprehensive clinical, neurophysiological, and morphological examination was made in 42 patients with chronic alcoholintoxication during this study. All the patients underwent skeletal muscle biopsy followed by muscle fiber morphometry. There was both selective type 2 muscle fiber atrophy and diffuse types 1 and 2 muscle fiber atrophic changes. The clinical manifestations of skeletal muscle disease corresponded to the degree of an atrophic process. There was impairment in the main components of protein synthesis at both intracellular and systemic regulation levels.
ISSN:2222-8721
2413-0443
DOI:10.17650/2222-8721-2013-0-2-35-38