Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects c...

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Bibliographic Details
Published in:Stem cell research & therapy 2022-01, Vol.13 (1), p.38-38, Article 38
Main Authors: Chen, Yuanting, Huang, Huacong, Li, Gaoxing, Yu, Jianyu, Fang, Fuchun, Qiu, Wei
Format: Article
Language:English
Subjects:
Biological activity
Cell culture
Cell sheets
Clinical trials
Cytokines
Decellularized
Dental pulp
Dental-derived mesenchymal stem cells
Disease
Endodontics
Enzymes
Extracellular Matrix
Graft rejection
Growth factors
Health aspects
Medicine
Membrane separation
Mesenchymal Stem Cells
Methods
Polymers
Regenerative medicine
Regenerative Medicine - methods
Review
Side effects
Signal transduction
Stem cell research
Stem Cells
Teeth
Temperature
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
Transplantation
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Summary:Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-based therapy, which is impactful in regenerative medicine. Emerging evidences show that cell sheets derived from DMSCs have better effects in the field of regenerative medicine applications. Extracellular matrix (ECM) is the main component of cell sheets, which is a dynamic repository of signalling biological molecules and has a variety of biological functions and may play an important role in the application of cell sheets. In this review, we summarized the application status, mechanisms that sheets and ECM may play and future prospect of DMSC sheets on regeneration medicine.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-02716-3