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Exploring Multi-Parameter Effects on Iron Oxide Nanoparticle Synthesis by SAXS Analysis
Iron oxide nanoparticles (IONs) are extensively used in biomedical applications due to their unique magnetic properties. This study optimized ION synthesis via the co-precipitation method, exploring the impact of the reactant concentrations (Fe(II) and Fe(III)), NaOH concentration, temperature (30 °...
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| Published in: | Crystals (Basel) 2024-11, Vol.14 (11), p.961 |
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| creator | Eigenfeld, Marco Reindl, Marco Sun, Xiao Schwaminger, Sebastian P |
| description | Iron oxide nanoparticles (IONs) are extensively used in biomedical applications due to their unique magnetic properties. This study optimized ION synthesis via the co-precipitation method, exploring the impact of the reactant concentrations (Fe(II) and Fe(III)), NaOH concentration, temperature (30 °C–80 °C), stirring speed (0–1000 rpm), and dosing rate (10–600 s) on particle size and growth. Using small-angle X-ray scattering (SAXS), we observed, for example, that higher temperatures (e.g., 67 °C compared with 53 °C) led to a 50% increase in particle size, while the stirring speed and NaOH concentration also influenced nucleation and aggregation. These results provide comprehensive insights into optimizing synthetic conditions for targeted applications in biomedical fields, such as drug delivery and magnetic resonance imaging (MRI), where precise control over nanoparticle size and properties is crucial. |
| doi_str_mv | 10.3390/cryst14110961 |
| format | article |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | biomedical applications Biomedical engineering Biomedical materials Caustic soda Chemical synthesis Comparative analysis Cost analysis Drug delivery systems Drugs Experiments Ferric oxide Hyperthermia Iron compounds iron oxide nanoparticles Iron oxides Magnetic fields Magnetic properties Magnetic resonance imaging Medical research nanoparticle size nanoparticle synthesis Nanoparticles Nucleation nucleation and growth dynamics Particle size Small angle X ray scattering Stirring Vehicles X-rays |
| title | Exploring Multi-Parameter Effects on Iron Oxide Nanoparticle Synthesis by SAXS Analysis |
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