Ultraearly Intraventricular Hemorrhage Growth Predicts Early Neurologic Deterioration and Poor Functional Outcome After Acute Intracerebral Hemorrhage

• Published in: Journal of the American Heart Association 2023-11, Vol.12 (21), p.e031214-e031214
• Main Authors: Lv, Xin-Ni, Cheng, Jing, Liu, Xue-Yun, Liu, Jin-Cheng, Deng, Lan, Li, Zuo-Qiao, Pu, Ming-Jun, Chen, Chu, Li, Qi
• Format: Article
• Language: English
• Subjects: Cerebral Hemorrhage; early neurologic deterioration; Hematoma; Humans; intracerebral hemorrhage; intraventricular hemorrhage growth; Original Research; outcome; Predictive Value of Tests; Prognosis; Stroke - complications; Tomography, X-Ray Computed
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.123.031214

Background The presence of intraventricular hemorrhage (IVH) was extensively investigated and was associated with poor outcome in patients with intracerebral hemorrhage (ICH). However, the effect of the speed of ventricular bleeding on outcomes is unknown. Methods and Results We prospectively included patients with ICH who had baseline computed tomography scans within 6 hours after ictus between January 2016 and October 2021. The clinical characteristics were compared between patients with and without early neurologic deterioration (END). Ultraearly IVH growth (uIVHG) was defined as baseline IVH volume by onset-to-imaging time. The association between uIVHG and outcomes was assessed by using multivariable logistic regression analysis. We established the ultraearly IVH growth (uIVH) score and compared the areas under the receiver operating characteristic curves of the existing scores for predicting END. A total of 299 patients were finally enrolled. Of those, 38 patients (12.7%) experienced END at 24 hours and 89 patients (29.8%) had poor outcomes at 90 days. After adjustment for confounding factors, uIVHG (odds ratio, 1.061 [95% CI, 1.011-1.113]; =0.016) was independently associated with END in multivariable analysis. A prediction score was developed on the basis of the logistic model. The uIVH score was developed as a sum of individual points (0-6) based on age, hematoma volume, National Institutes of Health Stroke Scale, hematoma expansion, and uIVHG ≥2.5 mL/h. In comparison with the ICH score and modified Emergency Department ICH Scale, the uIVH score exhibited best performance in the prediction of END. Conclusions uIVHG is associated with early neurologic deterioration and poor functional outcome in patients with ICH.