Micronuclei frequencies and nuclear abnormalities in oral exfoliated cells of nuclear power plant workers

Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. Micronucleus...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical and diagnostic research 2014-12, Vol.8 (12), p.ZC15-ZC17
Main Authors: Sagari, Shitalkumar G, Babannavar, Roopa, Lohra, Abhishek, Kodgi, Ashwin, Bapure, Sunil, Rao, Yogesh, J, Arun, Malghan, Manjunath
Format: Article
Language:English
Subjects:
Dentistry Section
dna damage
exfoliative cytology
genotoxicity
micronucleus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens (Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workers with absence of Leukemia and any malignancy (Group II) and workers diagnosed as leukemic patients and undergoing treatment (Group III). There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in Leukemic Patients were significantly higher than those in exposed workers &control groups (p < 0.05). MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is a need to educate those who work in NPS about the potential hazard of occupational exposure and the importance of using protective measures.
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2014/9059.5240