Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

• Published in: Lipids in health and disease 2020-01, Vol.19 (1), p.14-14, Article 14
• Main Authors: Teixeira, Giovana Rampazzo, Mendes, Leonardo Oliveira, Veras, Allice Santos Cruz, Thorpe, Hayley Hope Allyssa, Fávaro, Wagner José, de Almeida Chuffa, Luiz Gustavo, Pinheiro, Patrícia Fernanda Felipe, Martinez, Francisco Eduardo
• Format: Article
• Language: English
• Subjects: Androgens; Animals; Apoptosis; Apoptosis - physiology; Bax protein; Bcl-2 protein; bcl-2-Associated X Protein - metabolism; Biotechnology; Blotting, Western; Body weight gain; Caspase-3; CD36; CD36 antigen; CD36 Antigens - metabolism; Cholesterol; Development and progression; Eating; Exercise; Fatty acids; Feeds; Food; Health aspects; Hormones; Immunoglobulins; Immunohistochemistry; Insulin; Insulin-like growth factor I; Insulin-like growth factors; Kinases; Lifestyles; Lipid metabolism; Lipid Metabolism - physiology; Lipids; Male; Membrane proteins; Metabolism; Novels; Physical exercise; Physical fitness; Physical training; Physiological aspects; Prostate - metabolism; Prostate cancer; Protein binding; Proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats; Rats, Wistar; Resistance Training; Risk factors; SCAP; Sex hormones; SREBP-1; Sterol regulatory element-binding protein; Strength training; Testosterone; Weight training
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-020-1195-0

Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.