Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model

• Published in: BMC biotechnology 2024-09, Vol.24 (1), p.61-15, Article 61
• Main Authors: Thabit, Rabab M, El-Aziz, Fatma El-Zahraa A Abd, El-Fadl, A Abu, Abu-Sehly, A A, Sayed, Ahmed M
• Format: Article
• Language: English
• Subjects: Al-MOF; Aluminum; Aluminum - chemistry; Aluminum compounds; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-inflammatory drugs; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Bioavailability; Biological activities; Biomedical materials; Body fluids; Chemical properties; Coumarins; Drug Carriers - chemistry; Drug delivery; Drug delivery systems; Drug Liberation; Drugs; Earthworms; Encapsulation; Enzymes; Ethanol; Fourier transforms; Free radicals; Gravimetric analysis; Health aspects; In vitro methods and tests; Inflammation; Infrared analysis; Infrared spectroscopy; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Morphology; Nanoparticles; Nanoparticles - chemistry; Nitrates; Oligochaeta - drug effects; Oxidative stress; Pharmaceutical research; Phosphates; Protein expression; Proteins; Spectroscopy; Temperature; Thermal analysis; Thermal stability; Thermogravimetric analysis; Transmission electron microscopy; Umbelliferon; Umbelliferones - chemistry; Umbelliferones - pharmacology; Vehicles; Worms; Wound healing; Wound Healing - drug effects
• ISSN: 1472-6750; 1472-6750
• DOI: 10.1186/s12896-024-00889-8

Nanoporous aluminum metal-organic framework (Al-MOF) was synthesized via solvothermal methods and employed as a carrier matrix for in vitro drug delivery of Umbelliferon (Um). The encapsulated Um was gradually released over seven days at 37 °C, using simulated body fluid phosphate-buffered saline (PBS) at pH 7.4 as the release medium. The drug release profile suggests the potential of Al-MOF nanoparticles as effective drug delivery carriers. Structural and chemical analyses of Um-loaded Al-MOF nanoparticles (Um-Al MOF) were conducted using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), and ultraviolet-visible (UV-Vis) spectroscopy. Thermal gravimetric analysis (TGA) was employed to investigate the thermal stability of the Al-MOF nanoparticles, while Transmission Electron Microscopy (TEM) was utilized to assess their morphological features. Um-Al MOF nanoparticles demonstrated notable antioxidant and anti-inflammatory properties compared to Um and Al-MOF nanoparticles individually. Moreover, they exhibited significant enhancement in wound healing in an earthworm model. These findings underscore the potential of Al-MOF nanoparticles as a promising drug delivery system, necessitating further investigations to explore their clinical applicability.