Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts

L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivati...

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Bibliographic Details
Published in:Toxins 2019-05, Vol.11 (5), p.286
Main Authors: Degola, Francesca, Marzouk, Belsem, Gori, Antonella, Brunetti, Cecilia, Dramis, Lucia, Gelati, Stefania, Buschini, Annamaria, Restivo, Francesco M
Format: Article
Language:English
Subjects:
Aflatoxins
Aflatoxins - metabolism
Analgesics
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
antimycotoxigenic activity
Antioxidants
Arthritis
Aspergillus flavus
Aspergillus flavus - drug effects
Aspergillus flavus - growth & development
Aspergillus flavus - metabolism
Biological activity
Biosynthesis
Bronchitis
Citrullus colocynthis
Diabetes mellitus
Epilepsy
HPLC-MS/MS
Hypertension
Inflammation
Mastitis
Medicinal plants
Medicine
model system
Model testing
Molecular weight
Organs
Oxidative stress
Pharmacology
Phytochemicals
Phytochemicals - analysis
Phytochemicals - pharmacology
Phytopathogenic fungi
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves
Plant Roots
Plant Stems
Solvents
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Summary:L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of are used in folk Berber medicine for the treatment of numerous diseases-such as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus , testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins11050286