Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells

Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a...

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Published in:Pharmaceutics 2021-10, Vol.13 (11), p.1763
Main Authors: Martins, Núbia Sabrina, de Campos Fraga-Silva, Thais Fernanda, Correa, Giseli Furlan, Boko, Mèdéton Mahoussi Michaël, Ramalho, Leandra Naira Zambelli, Rodrigues, Débora Munhoz, Hori, Juliana Issa, Costa, Diego Luis, Bastos, Jairo Kenupp, Bonato, Vânia Luiza Deperon
Format: Article
Language:English
Subjects:
Allergens
allergic asthma
Allergies
Animals
artepillin C
Asthma
Bone marrow
Chromatography
Cytokines
Disease
Experiments
Inflammation
Laboratories
Lavage
Lymphocytes
M-MDSC
propolis
therapies
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Summary:Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a previous study, our group showed that green propolis treatment reduced airway inflammation and mucus secretion in an ovalbumin (OVA)-induced asthma model and resulted in increased regulatory T cells (Treg) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) frequencies in the lungs, two leukocyte populations that have immunosuppressive functions. In this study, we evaluated the anti-inflammatory effects of artepillin C (ArtC), the major compound of green propolis, in the context of allergic airway inflammation. Our results show that ArtC induces in vitro differentiation of Treg cells and monocytic MDSC (M-MDSC). Furthermore, in an OVA-induced asthma model, ArtC treatment reduced pulmonary inflammation, eosinophil influx to the airways, mucus and IL-5 secretion along with increased frequency of M-MDSC, but not Treg cells, in the lungs. Using an adoptive transfer model, we confirmed that the effect of ArtC in the reduction in airway inflammation was dependent on M-MDSC. Altogether, our data show that ArtC exhibits an anti-inflammatory effect and might be an adjuvant therapy for allergic asthma.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13111763