Growth factors in the treatment of oral mucositis in patients receiving treatment for head and neck cancers - A review

Many cancer patients undergoing systemic chemotherapy or radiotherapy or a combination of both, especially in head and neck region, are inherently prone to develop a frequent complication i.e. oral mucositis. This acute and distressing sequel of cancer therapy drastically impairs routine activities...

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Bibliographic Details
Published in:Journal of Indian Academy of Oral Medicine and Radiology 2019-04, Vol.31 (2), p.162-166, Article 162
Main Authors: Soni, Pratima, Garlapati, Komali, Kammari, Anuja, Guduru, Harika
Format: Article
Language:English
Subjects:
Antineoplastic agents
Bone marrow
Cancer patients
Cancer therapies
Cancer treatment
Care and treatment
Chemotherapy
Clinical trials
Colony-stimulating factor
Comparative studies
Cytokines
Dental implants
Disease management
Embryogenesis
epidermal growth factor
Granulocytes
Growth factors
Head & neck cancer
Health aspects
Hematology
keratiocyte growth factor
Kinases
Mastication
Mimicry
Mucositis
Neck
Neutrophils
oral mucositis
Pain
Palifermin
Patients
Prevention
Quality of life
Radiation therapy
Radiotherapy
Stem cells
Stomatitis
transforming growth factor
Transplants & implants
Ulcers
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Summary:Many cancer patients undergoing systemic chemotherapy or radiotherapy or a combination of both, especially in head and neck region, are inherently prone to develop a frequent complication i.e. oral mucositis. This acute and distressing sequel of cancer therapy drastically impairs routine activities such as mastication, deglutition, and speech thereby affecting the overall quality of life of these patients. Because of the complex nature of oral mucositis, its management becomes challenging. An in-depth understanding of the etiopathogenesis of oral mucositis has provided numerous treatment options, but none with a proper guideline. Recent years have also seen a considerable emphasis on growth factors, which has led to the recognition that they might have potential in the therapeutic management of these complications, either by regeneration through biomimetic or mimicking the processes that occur during embryonic and post-natal development. As the understanding of the biological and physiological role of growth factors increases, it is certain that they will play an increasingly important role in clinical insights. This review attempts to highlight the role of growth factors in the management of oral mucositis.
ISSN:0972-1363
0975-1572
DOI:10.4103/jiaomr.jiaomr_176_18