LASI-DAD study: a protocol for a prospective cohort study of late-life cognition and dementia in India

IntroductionAlzheimer’s disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Alth...

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Bibliographic Details
Published in:BMJ open 2019-07, Vol.9 (7), p.e030300-e030300
Main Authors: Lee, Jinkook, Banerjee, Joyita, Khobragade, Pranali Yogiraj, Angrisani, Marco, Dey, A B
Format: Article
Language:English
Subjects:
Aged
Aging
Air pollution
Alzheimer's disease
Blood Chemical Analysis
Brain research
Cognition
Cognition & reasoning
Cognitive ability
Cohort analysis
Cohort Studies
Data collection
Dementia
Dementia - epidemiology
Epidemiology
Estimates
Geriatric Assessment
Geriatrics
Humans
India
Interviews
Laboratories
Medical imaging
Middle Aged
Neuroimaging
Neuropsychological Tests
Outdoor air quality
Population
Research Design
Risk Factors
Sampling Studies
Society
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Summary:IntroductionAlzheimer’s disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burden of dementia presents an urgent challenge for India, previous efforts to study dementia in the country have relied on non-representative samples in geographically restricted regions. The Harmonised Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) will provide rich, population-representative data on late-life cognition and dementia and their risk factors for the first time in India.MethodsThe LASI-DAD will recruit a sample of 3000 people aged 60+ years. Their family members or friends, whom respondents nominate as informants, participate in the computer-assisted personal interview. The study sample is drawn from the ongoing, nationally representative Longitudinal Aging Study in India, a multipurpose panel survey of aging. We aim to collect rich data on cognitive and neuropsychological tests, informant reports, and epidemiological data through a comprehensive geriatric assessment, and venous blood collection and assays. For a subsample, we collect neuroimaging data. Data collection is currently in progress in 14 States and Union Territories of India. Clinicians will provide clinical consensus diagnosis based on the Clinical Dementia Rating.Ethics and disseminationEthics approval was obtained from the Indian Council of Medical Research and all collaborating institutions. Anonymised data will be available for the larger research community through a secured website hosted by the Gateway to Global Aging Data platform. Research findings from the LASI-DAD team will be disseminated through journal publications and presentations at professional conferences.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2019-030300