The Relationship between Muscle Ultrasound Parameters and Diabetic Peripheral Neuropathy among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Background. Muscle dysfunction is an early complication of diabetic peripheral neuropathy (DPN). As a convenient and low-cost tool, muscle ultrasound has been used to assess muscle quality and muscle mass. However, the relationship between different muscle ultrasound parameters and DPN is unclear. O...

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Bibliographic Details
Published in:Journal of diabetes research 2023, Vol.2023, p.8897065-7
Main Authors: Zhong, Yanling, Liu, Xiaojia, Lin, Teng
Format: Article
Language:English
Subjects:
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetic Neuropathies - diagnosis
Foot diseases
Humans
Muscle strength
Muscle, Skeletal - diagnostic imaging
Older people
Perception - physiology
Peripheral Arterial Disease - complications
Peripheral neuropathy
Sarcopenia
Ultrasonic imaging
Velocity
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Summary:Background. Muscle dysfunction is an early complication of diabetic peripheral neuropathy (DPN). As a convenient and low-cost tool, muscle ultrasound has been used to assess muscle quality and muscle mass. However, the relationship between different muscle ultrasound parameters and DPN is unclear. Objectives. This study was designed to investigate the relationship between ultrasound parameters of different muscles and DPN among patients with type 2 diabetes mellitus, including the rectus femoris (RF), tibialis anterior (TA), and medial head of gastrocnemius (MG). Materials and Methods. The research enrolled 90 patients with type 2 diabetes mellitus (T2DM). All images were attained from both sides. Muscle measurements contained muscle thickness (MT), cross-sectional area (CSA), echo intensity (EI), and corrected EI. The binary logistic regression and multiple linear regression were used to investigate the association between muscle ultrasound parameters and DPN or vibration perception threshold (VPT). Results. EI, corrected EI, MT of MG, and EI of TA were associated with DPN separately after adjusting other clinical variates. Among these muscle parameters, the EI of MG had a better predictive value (OR: 1.114, 95% CI: 1.039, 1.196) of DPN. Combined with CSA of RF, peripheral artery disease (PAD), and sex, the corrected EI of MG was associated with the vibration perception threshold (VPT) (standard β=0.242, p
ISSN:2314-6745
2314-6753
DOI:10.1155/2023/8897065