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Polymer based microneedle patch fabricated using microinjection moulding
This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engi...
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Published in: | MATEC web of conferences 2018-01, Vol.192, p.1039 |
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creator | Janphuang, Pattanaphong Laebua, Mongkhol Sriphung, Chanwut Taweewat, Phatsakon Sirichalarmkul, Anan Sukjantha, Kasiphisan Promsawat, Napatporn Leuasoongnoen, Pimchanok Suphachiaraphan, Somphong Phimol, Kantapon Isarakorn, Don Tancharakorn, Somchai |
description | This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engineering (CAE) software. A mould insert with low surface roughness was fabricated using Micro Electrical Discharge Machining (μ-EDM). The injection moulding parameters including clamping force, temperature, injection pressure and velocity were characterized in order to obtain the optimum reproducibility. Solid truncated cone microneedles, made of biocompatible polymethyl methacrylate (PMMA), with a round tip radius of 50 μm and 500 μm in height have been realized by microinjection moulding process demonstrating the potential of a low cost, high production efficiency, and suitable for mass production. In addition, a mould insert of cylindrical microneedles fabricated using X-ray LIGA has been proposed. |
doi_str_mv | 10.1051/matecconf/201819201039 |
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Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3129-f0798336afe74ccf3d3e0eb4c11ed9df338804dc4b10802386fdea0a50a181903</citedby><cites>FETCH-LOGICAL-c3129-f0798336afe74ccf3d3e0eb4c11ed9df338804dc4b10802386fdea0a50a181903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2303227574?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119,25732,27903,27904,36991,44569</link.rule.ids></links><search><contributor>Hamontree, C.</contributor><creatorcontrib>Janphuang, Pattanaphong</creatorcontrib><creatorcontrib>Laebua, Mongkhol</creatorcontrib><creatorcontrib>Sriphung, Chanwut</creatorcontrib><creatorcontrib>Taweewat, Phatsakon</creatorcontrib><creatorcontrib>Sirichalarmkul, Anan</creatorcontrib><creatorcontrib>Sukjantha, Kasiphisan</creatorcontrib><creatorcontrib>Promsawat, Napatporn</creatorcontrib><creatorcontrib>Leuasoongnoen, Pimchanok</creatorcontrib><creatorcontrib>Suphachiaraphan, Somphong</creatorcontrib><creatorcontrib>Phimol, Kantapon</creatorcontrib><creatorcontrib>Isarakorn, Don</creatorcontrib><creatorcontrib>Tancharakorn, Somchai</creatorcontrib><title>Polymer based microneedle patch fabricated using microinjection moulding</title><title>MATEC web of conferences</title><description>This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. 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Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engineering (CAE) software. A mould insert with low surface roughness was fabricated using Micro Electrical Discharge Machining (μ-EDM). The injection moulding parameters including clamping force, temperature, injection pressure and velocity were characterized in order to obtain the optimum reproducibility. Solid truncated cone microneedles, made of biocompatible polymethyl methacrylate (PMMA), with a round tip radius of 50 μm and 500 μm in height have been realized by microinjection moulding process demonstrating the potential of a low cost, high production efficiency, and suitable for mass production. In addition, a mould insert of cylindrical microneedles fabricated using X-ray LIGA has been proposed.</abstract><cop>Les Ulis</cop><pub>EDP Sciences</pub><doi>10.1051/matecconf/201819201039</doi><oa>free_for_read</oa></addata></record> |
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subjects | Biocompatibility CAE Computer aided engineering Drug delivery systems Electric discharge machining Injection molding Mass production Molds Needles Polymethyl methacrylate Software engineering Surface roughness Transdermal medication |
title | Polymer based microneedle patch fabricated using microinjection moulding |
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