Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams

Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active molecules. They can be often synthesized by means of multicomponent approaches and recent contributions in this field are summarized in this review. Clear advantages of thes...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2019, Vol.15 (1), p.1065-1085
Main Authors: de Marigorta, Edorta Martínez, Santos, Jesús M de Los, Ochoa de Retana, Ana M, Vicario, Javier, Palacios, Francisco
Format: Article
Language:English
Subjects:
2-oxindoles
Acids
Chemistry
Enantiomers
indolin-2-ones
isoindolinones
Ligands
multicomponent reactions
Natural products
Nonsteroidal anti-inflammatory drugs
Pharmaceutical sciences
Review
γ-lactams
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Summary:Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active molecules. They can be often synthesized by means of multicomponent approaches and recent contributions in this field are summarized in this review. Clear advantages of these methods include the efficiency in saving raw materials and working time. However, there is still a need of new catalytic systems to allow the enantioselective preparation of these heterocycles by multicomponent reactions.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.15.104