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Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats
PURPOSE: To evaluate the tissue integration of a double-sided mesh after fixation in diaphragm and to study the diaphragmatic mobility by ultrasound. METHODS: Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia. The animals were anest...
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Published in: | Acta cirúrgica brasileira 2016-04, Vol.31 (4), p.235-242 |
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container_title | Acta cirúrgica brasileira |
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creator | Ioannis, Tzanoglou George, Sakorafas Nikolaos, Kostomitsopoulos George, Mantziaras Charalampos, Patraleksis Nikolaos, Danias Spyridon, Stergiopoulos Michael, Safioleas |
description | PURPOSE: To evaluate the tissue integration of a double-sided mesh after fixation in diaphragm and to study the diaphragmatic mobility by ultrasound. METHODS: Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia. The animals were anesthetized and a 1.5 x 1.5 cm of double-layer mesh was inserted between the diaphragm and the liver. For the evaluation of the diaphragm mobility a sonographic method was used. Measurements on specific breathing parameters were taking place. Pathological evaluation took place after the animal's euthanasia. RESULTS: Extra-hepatic granuloma was not differentiated overtime, (χ2=0.04, p>0.05). Neither fibrosis was significantly differentiated, (χ2=0.04, p>0.05). Intra-hepatic granuloma was significantly differentiated overtime, (χ2=10.21, p |
doi_str_mv | 10.1590/S0102-865020160040000003 |
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METHODS: Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia. The animals were anesthetized and a 1.5 x 1.5 cm of double-layer mesh was inserted between the diaphragm and the liver. For the evaluation of the diaphragm mobility a sonographic method was used. Measurements on specific breathing parameters were taking place. Pathological evaluation took place after the animal's euthanasia. RESULTS: Extra-hepatic granuloma was not differentiated overtime, (χ2=0.04, p>0.05). Neither fibrosis was significantly differentiated, (χ2=0.04, p>0.05). Intra-hepatic granuloma was significantly differentiated overtime, (χ2=10.21, p<0.05). Concerning Te parameter, means were significantly differentiated over time, F (3, 30) = 5.12, (p<0.01). Ttot parameter, it was differentiated over time, F (3, 8)=4.79, (p<0.05). IR parameter was also longitudinally differentiated, F (3, 30)=3.73, (p<0.05). CONCLUSION: The measurements suggest a transient malfunction of diaphragmatic mobility despite the fact that inflammatory reaction, fibrosis and extra-hepatic granuloma were not significantly differentiated with the passage of time.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-865020160040000003</identifier><language>eng</language><publisher>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</publisher><subject>Diaphragm ; Fibrosis ; Foreign-Body Reaction ; Rats ; Surgical Mesh</subject><ispartof>Acta cirúrgica brasileira, 2016-04, Vol.31 (4), p.235-242</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-c9bba5f8d5aac805bcfd27c37506f8474beaacb6c8df3846765de39a574ad2843</citedby><cites>FETCH-LOGICAL-c470t-c9bba5f8d5aac805bcfd27c37506f8474beaacb6c8df3846765de39a574ad2843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ioannis, Tzanoglou</creatorcontrib><creatorcontrib>George, Sakorafas</creatorcontrib><creatorcontrib>Nikolaos, Kostomitsopoulos</creatorcontrib><creatorcontrib>George, Mantziaras</creatorcontrib><creatorcontrib>Charalampos, Patraleksis</creatorcontrib><creatorcontrib>Nikolaos, Danias</creatorcontrib><creatorcontrib>Spyridon, Stergiopoulos</creatorcontrib><creatorcontrib>Michael, Safioleas</creatorcontrib><title>Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats</title><title>Acta cirúrgica brasileira</title><description>PURPOSE: To evaluate the tissue integration of a double-sided mesh after fixation in diaphragm and to study the diaphragmatic mobility by ultrasound. METHODS: Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia. The animals were anesthetized and a 1.5 x 1.5 cm of double-layer mesh was inserted between the diaphragm and the liver. For the evaluation of the diaphragm mobility a sonographic method was used. Measurements on specific breathing parameters were taking place. Pathological evaluation took place after the animal's euthanasia. RESULTS: Extra-hepatic granuloma was not differentiated overtime, (χ2=0.04, p>0.05). Neither fibrosis was significantly differentiated, (χ2=0.04, p>0.05). Intra-hepatic granuloma was significantly differentiated overtime, (χ2=10.21, p<0.05). Concerning Te parameter, means were significantly differentiated over time, F (3, 30) = 5.12, (p<0.01). Ttot parameter, it was differentiated over time, F (3, 8)=4.79, (p<0.05). IR parameter was also longitudinally differentiated, F (3, 30)=3.73, (p<0.05). CONCLUSION: The measurements suggest a transient malfunction of diaphragmatic mobility despite the fact that inflammatory reaction, fibrosis and extra-hepatic granuloma were not significantly differentiated with the passage of time.</description><subject>Diaphragm</subject><subject>Fibrosis</subject><subject>Foreign-Body Reaction</subject><subject>Rats</subject><subject>Surgical Mesh</subject><issn>0102-8650</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNplkd1Kw0AQhRdRsFbfYV8gOkl2N5tLKfUHCl6o12H2r92yyZZNqtanN7ZSFOdmhnOYjwOHEJrDdc5ruHmGHIpMCg4F5AKAwX7KEzI5Oqe_7nNy0fdrgJyJvJyQz_kbhi0OPnY0Omo8blYJl-2oaNpG5YMfdtTFEOK775bUd0PCDJWJre8w0H6rsr9Pzn8ccUhN3Kpgs4A7m6yhre1XI4MmHPpLcuYw9PbqZ0_J6938ZfaQLZ7uH2e3i0yzCoZM10ohd9JwRC2BK-1MUemy4iCcZBVTdjSU0NK4UjJRCW5sWSOvGJpCsnJKHg9cE3HdbJJvMe2aiL7ZCzEtG0xj8mCbEa55pXVVcsd0zdGCEzZXSoEwTsmRJQ8snWLfJ-uOvBya7z6afR_N_z7KL-s1gf8</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Ioannis, Tzanoglou</creator><creator>George, Sakorafas</creator><creator>Nikolaos, Kostomitsopoulos</creator><creator>George, Mantziaras</creator><creator>Charalampos, Patraleksis</creator><creator>Nikolaos, Danias</creator><creator>Spyridon, Stergiopoulos</creator><creator>Michael, Safioleas</creator><general>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</general><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>201604</creationdate><title>Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats</title><author>Ioannis, Tzanoglou ; George, Sakorafas ; Nikolaos, Kostomitsopoulos ; George, Mantziaras ; Charalampos, Patraleksis ; Nikolaos, Danias ; Spyridon, Stergiopoulos ; Michael, Safioleas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-c9bba5f8d5aac805bcfd27c37506f8474beaacb6c8df3846765de39a574ad2843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Diaphragm</topic><topic>Fibrosis</topic><topic>Foreign-Body Reaction</topic><topic>Rats</topic><topic>Surgical Mesh</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ioannis, Tzanoglou</creatorcontrib><creatorcontrib>George, Sakorafas</creatorcontrib><creatorcontrib>Nikolaos, Kostomitsopoulos</creatorcontrib><creatorcontrib>George, Mantziaras</creatorcontrib><creatorcontrib>Charalampos, Patraleksis</creatorcontrib><creatorcontrib>Nikolaos, Danias</creatorcontrib><creatorcontrib>Spyridon, Stergiopoulos</creatorcontrib><creatorcontrib>Michael, Safioleas</creatorcontrib><collection>CrossRef</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Acta cirúrgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ioannis, Tzanoglou</au><au>George, Sakorafas</au><au>Nikolaos, Kostomitsopoulos</au><au>George, Mantziaras</au><au>Charalampos, Patraleksis</au><au>Nikolaos, Danias</au><au>Spyridon, Stergiopoulos</au><au>Michael, Safioleas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats</atitle><jtitle>Acta cirúrgica brasileira</jtitle><date>2016-04</date><risdate>2016</risdate><volume>31</volume><issue>4</issue><spage>235</spage><epage>242</epage><pages>235-242</pages><issn>0102-8650</issn><eissn>0102-8650</eissn><abstract>PURPOSE: To evaluate the tissue integration of a double-sided mesh after fixation in diaphragm and to study the diaphragmatic mobility by ultrasound. METHODS: Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia. The animals were anesthetized and a 1.5 x 1.5 cm of double-layer mesh was inserted between the diaphragm and the liver. For the evaluation of the diaphragm mobility a sonographic method was used. Measurements on specific breathing parameters were taking place. Pathological evaluation took place after the animal's euthanasia. RESULTS: Extra-hepatic granuloma was not differentiated overtime, (χ2=0.04, p>0.05). Neither fibrosis was significantly differentiated, (χ2=0.04, p>0.05). Intra-hepatic granuloma was significantly differentiated overtime, (χ2=10.21, p<0.05). Concerning Te parameter, means were significantly differentiated over time, F (3, 30) = 5.12, (p<0.01). Ttot parameter, it was differentiated over time, F (3, 8)=4.79, (p<0.05). IR parameter was also longitudinally differentiated, F (3, 30)=3.73, (p<0.05). CONCLUSION: The measurements suggest a transient malfunction of diaphragmatic mobility despite the fact that inflammatory reaction, fibrosis and extra-hepatic granuloma were not significantly differentiated with the passage of time.</abstract><pub>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</pub><doi>10.1590/S0102-865020160040000003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Diaphragm Fibrosis Foreign-Body Reaction Rats Surgical Mesh |
title | Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats |
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