Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types

In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate with...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2016-05, Vol.17 (5), p.790-790
Main Authors: Scognamiglio, Giosuè, De Chiara, Anna, Di Bonito, Maurizio, Tatangelo, Fabiana, Losito, Nunzia Simona, Anniciello, Annamaria, De Cecio, Rossella, D'Alterio, Crescenzo, Scala, Stefania, Cantile, Monica, Botti, Gerardo
Format: Article
Language:English
Subjects:
B7-H1 Antigen - metabolism
Humans
immunohistochemical staining
Immunohistochemistry - methods
Immunohistochemistry - standards
Neoplasms - diagnosis
Neoplasms - metabolism
Organ Specificity
PD-L1
Sensitivity and Specificity
tissue type’s variability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate with a poor prognosis of patients with several types of cancer. However, recent reports have revealed that the immunohistochemical (IHC) expression of the PD-L1 in tumor cells is not uniform for the use of different antibodies clones, with variable specificity, often doubtful topographical localization, and with a score not uniquely defined. The purpose of this study was to analyze the IHC expression of PD-L1 on a large series of several human tumors to correctly define its staining in different tumor tissues.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms17050790